Oclacitinib
Cat. No.：YN340137
CAS No. ：1208319-26-9
| 产品名称: | Oclacitinib |
| CAS No.: | 1208319-26-9 |
| Chemical Name: | trans-N-methyl-4-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-cyclohexanemethanesulfonamide |
| Synonyms: | PF-03394197 |
| 分子量: | 337.44 |
| 分子式: | C₁₅H₂₃N₅O₂S |
| SMILES: | O=S(C[C@H]1CC[C@H](N(C)C2=C3C(NC=C3)=NC=N2)CC1)(NC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Oclacitinib 是一种新型JAK抑制剂。Oclacitinib 抑制JAK1最有效，IC50为 10 nM。 |
| IC50和靶点: | |
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Gonzales, A.J., Bowman, J.W., Fici, G.J., et al.Oclacitinib (APOQUEL®) is a novel Janus kinase inhibitor with activity against cytokines involved in allergyJ. Vet. Pharmacol. Ther.37(4),317-324(2014)
Fukuyama, T., Ehling, S., Cook, E., et al.Topically administered Janus-kinase inhibitors ofacitinib and olacitinib dsplay impressive antipruritic and anti-inflammatory responses in a model of allergic dermatitisJ. Pharmacol. Exp. Ther.354(3),394-405(2015)
