BMS-911543
Cat. No.：YN340168
CAS No. ：1271022-90-2
| 产品名称: | BMS-911543 |
| CAS No.: | 1271022-90-2 |
| Chemical Name: | N,N-dicyclopropyl-4-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-6-ethyl-1,6-dihydro-1-methyl-imidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide |
| Synonyms: | BMS911543 |
| 分子量: | 432.52 |
| 分子式: | C₂₃H₂₈N₈O |
| SMILES: | O=C(C1=CC2=C(N(C)C=N3)C3=C(NC4=NN(C)C(C)=C4)N=C2N1CC)N(C5CC5)C6CC6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS-911543 是一种选择性的JAK2抑制剂，IC50值为 1.1 nM，对 JAK1，JAK3 和 TYK2 的选择性相对较弱，IC50值分别为 75，360 和 66 nM。 |
| IC50和靶点: | [{name:"JAK2:1.1 nM (IC50)"},{name: "Tyk2:66 nM (IC50)"},{name: "JAK1:75 nM (IC50)"},{name: "JAK3:360 nM (IC50)"}] |
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Purandare, A.V., McDevitt, T.M., Wan, H.Y., D., et al.Characterization of BMS-911543, a functionally selective small-molecule inhibitor of JAK2Leukemia26(2),280-288(2012)
Wan, H., Schroeder, G.M., Hart, A.C., et al.Discovery of a highly selective JAK2 inhibitor, BMS-911543, for the treatment of myeloproliferative neoplasmsACS Med. Chem. Lett.6(8),850-855(2015)
Pomicter, A.D., Eiring, A.M., Senina, A.V., et al.Limited efficacy of BMS-911543 in a murine model of Janus kinase 2 V617F myeloproliferative neoplasmExp. Hematol.43(7),537-545(2015)
