WP1066
Cat. No.：YN340169
| 产品名称: | WP1066 |
| CAS No.: | 857064-38-1 |
| Chemical Name: | 3-(6-bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethyl]-2E-propenamide |
| Synonyms: | wp1066, wp 1066,wp-1066 |
| 分子量: | 356.22 |
| 分子式: | C₁₇H₁₄BrN₃O |
| SMILES: | O=C(N[C@H](C1=CC=CC=C1)C)/C(C#N)=C/C2=NC(Br)=CC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WP1066 是一种新颖的JAK2和STAT3抑制剂，对 STAT5 和 ERK1/2 也起作用，但对 JAK1 和 JAK3 没有影响。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Iwamura, A., Szymanski, S., Iwado, E., et al.A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivoOncogene26(17),2435-2444(2007)
Hussain, S.F., Kong, L.Y., Jordan, J., et al.A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patientsCancer Res.67(20),9630-9636(2007)
Ferrajoli, A., Faderl, S., Van, Q., et al.WP1066 disrupts janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cellsCancer Res.67(23),11291-11299(2007)
Daniel, J.M., Dutzmann, J., Bielenberg, W., et al.Inhibition of STAT3 signaling prevents vascular smooth muscle cell proliferation and neointima formationBasic Res. Cardiol.107(3),261(2012)
Grabenstatter, H.L., Cruz Del Angel, Y., Carlsen, J., et al.The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsyNeurobiol. Dis.62,73-85(2013)
