Baricitinib
Cat. No.：YN340170
CAS No. ：1187594-09-7
| 产品名称: | Baricitinib |
| CAS No.: | 1187594-09-7 |
| Chemical Name: | 1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile |
| Synonyms: | 巴瑞克替尼; LY3009104; INCB028050 |
| 分子量: | 371.42 |
| 分子式: | C₁₆H₁₇N₇O₂S |
| SMILES: | N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(S(=O)(CC)=O)C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Baricitinib (LY3009104; INCB028050) 是选择性，可口服的JAK1和JAK2抑制剂，IC50分别为5.9 nM 和 5.7 nM。 |
| IC50和靶点: | [{name:"JAK2:5.7 nM (IC50)"},{name: "JAK1:5.9 nM (IC50)"},{name: "Tyk2:53 nM (IC50)"},{name: "JAK3:560 nM (IC50)"}] |
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| Solvent & Solubility: |
Fridman, J.S., Scherle, P.A., Collins, R., et al.Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: Preclinical characterization of INCB028050J. Immunol.184(9),5298-5307(2010)
Hoang, T.N., Pino, M., Boddapati, A.K., et al.Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaquesCell184(2),460-475(2021)
