NSC 42834
Cat. No.：YN340174
CAS No. ：195371-52-9
| 产品名称: | NSC 42834 |
| CAS No.: | 195371-52-9 |
| Chemical Name: | 2-methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]-1-butanone |
| Synonyms: | JAK2 Inhibitor V; Z3 |
| 分子量: | 344.45 |
| 分子式: | C₂₃H₂₄N₂O |
| SMILES: | O=C(C1=CC=CC=C1)C(CCC2=NC=CC=C2)(C)CCC3=NC=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NSC 42834 (JAK2 Inhibitor V) 是新型Jak2特异性抑制剂，能以剂量依赖的形式抑制 Jak2-V617F 和 Jak2-WT 的自磷酸化。 |
| IC50和靶点: | [{name:"JAK2-WT:15 μM (IC50)"},{name: "JAK2-V617F:28 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Gozgit, J.M., Bebernitz, G., Patil, P., et al.Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2J. Biol. Chem.283(47),32334-32343(2008)
Sayyah, J., Magis, A., Ostrov, D.A., et al.Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growthMol. Cancer Ther.7(8),2308-2318(2008)
