Cerdulatinib
Cat. No.：YN340188
CAS No. ：1198300-79-6
| 产品名称: | Cerdulatinib |
| CAS No.: | 1198300-79-6 |
| Chemical Name: | 4-(cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide |
| Synonyms: | PRT062070; PRT2070 |
| 分子量: | 445.54 |
| 分子式: | C₂₀H₂₇N₇O₃S |
| SMILES: | O=S(N(CC1)CCN1C2=CC=C(NC3=NC=C(C(N)=O)C(NC4CC4)=N3)C=C2)(CC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cerdulatinib (PRT062070) 是一种有效的选择性Tyk2抑制剂，IC50为 0.5 nM。Cerdulatinib (PRT062070) 是JAK和SYK的双抑制剂，抑制JAK1，2，3 和SYK的IC50分别为12，6，8 和 32。 |
| IC50和靶点: | [{name:"Tyk2:0.5 nM (IC50)"},{name: "JAK2:6 nM (IC50)"},{name: "JAK3:8 nM (IC50)"},{name: "JAK1:12 nM (IC50)"},{name: "Syk:32 nM (IC50)"},{name: "MST1:4 nM (IC50)"},{name: "ARK5:4 nM (IC50)"},{name: "MLK1:5 nM (IC50)"},{name: "FMS:5 nM (IC50)"},{name: "AMPK:6 nM (IC50)"},{name: "TBK1:10 nM (IC50)"},{name: "MARK1:10 nM (IC50)"},{name: "PAR1B-a:13 nM (IC50)"},{name: "TSSK:14 nM (IC50)"},{name: "MST2:15 nM (IC50)"},{name: "GCK:18 nM (IC50)"},{name: "JNK3:18 nM (IC50)"},{name: "Rsk2:20 nM (IC50)"},{name: "Rsk4:28 nM (IC50)"},{name: "CHK1:42 nM (IC50)"},{name: "Flt4:51 nM (IC50)"},{name: "Flt3:90 nM (IC50)"},{name: "Ret:105 nM (IC50)"},{name: "Itk:194 nM (IC50)"}] |
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Coffey, G., Betz, A., DeGuzman, F., et al.The novel kinase inhibitor PRT062070 (Cerdulatinib) demonstrates efficacy in models of autoimmunity and B-cell cancerJ. Pharmacol. Exp. Ther.351(3),538-548(2014)
Ma, J., Xing, W., Coffey, G., et al.Cerdulatinib, a novel dual SYK/JAK kinase inhibitor, has broad anti-tumor activity in both ABC and GCB types of diffuse large B cell lymphomaOncotarget6(41),43881-43896(2015)
