Cerdulatinib hydrochloride
Cat. No.：YN340189
CAS No. ：1369761-01-2
| 产品名称: | Cerdulatinib hydrochloride |
| CAS No.: | 1369761-01-2 |
| Chemical Name: | |
| Synonyms: | PRT062070 hydrochloride; PRT2070 hydrochloride |
| 分子量: | 482.00 |
| 分子式: | C₂₀H₂₈ClN₇O₃S |
| SMILES: | O=S(N(CC1)CCN1C2=CC=C(NC3=NC=C(C(N)=O)C(NC4CC4)=N3)C=C2)(CC)=O.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cerdulatinib hydrochloride (PRT062070) 是一种选择性，具有口服活性和可逆的 ATP 竞争性的SYK和JAK的双重抑制剂，抑制SYK和Tyk2、JAK1、2、3的IC50值分别为 32 nM、0.5 nM、12 nM、6 nM 和 8 nM。Cerdulatinib hydrochloride 可用于研究自身免疫性疾病和B细胞恶性肿瘤。 |
| IC50和靶点: | [{name:"Tyk2:0.5 nM (IC50)"},{name: "JAK1:12 nM (IC50)"},{name: "JAK2:6 nM (IC50)"},{name: "JAK3:8 nM (IC50)"},{name: "SYK:32 nM (IC50)"},{name: "MST1:4 nM (IC50)"},{name: "ARK5:4 nM (IC50)"},{name: "MLK1:5 nM (IC50)"},{name: "FMS:5 nM (IC50)"},{name: "AMPK:6 nM (IC50)"},{name: "TBK1:10 nM (IC50)"},{name: "MARK1:10 nM (IC50)"},{name: "PAR1B-a:13 nM (IC50)"},{name: "TSSK:14 nM (IC50)"},{name: "MST2:15 nM (IC50)"},{name: "GCK:18 nM (IC50)"},{name: "JNK3:18 nM (IC50)"},{name: "Rsk2:20 nM (IC50)"},{name: "Rsk4:28 nM (IC50)"},{name: "CHK1:42 nM (IC50)"},{name: "Flt4:51 nM (IC50)"},{name: "Flt3:90 nM (IC50)"},{name: "Ret:105 nM (IC50)"},{name: "Itk:194 nM (IC50)"}] |
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