Solcitinib
Cat. No.：YN340194
CAS No. ：1206163-45-2
| 产品名称: | Solcitinib |
| CAS No.: | 1206163-45-2 |
| Chemical Name: | N-[5-[4-[(3,3-dimethyl-1-azetidinyl)carbonyl]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxamide |
| Synonyms: | 索西替尼; GSK-2586184; GLPG-0778 |
| 分子量: | 389.45 |
| 分子式: | C₂₂H₂₃N₅O₂ |
| SMILES: | O=C(C1CC1)NC2=NN3C(C4=CC=C(C(N5CC(C)(C)C5)=O)C=C4)=CC=CC3=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Solcitinib 是一种可口服的，竞争性的，有效的，选择性的JAK1抑制剂，IC50值为 9.8 nM，对其选择性是对 JAK2，JAK3 和 TYK2 的 11，55 和 23 倍；Solcitinib 可用于银屑病的研究。 |
| IC50和靶点: | [{name:"JAK1:9.8 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ludbrook, V.J., Hicks, K.J., Hanrott, K.E., et al.Investigation of selective JAK1 inhibitor GSK2586184 for the treatment of psoriasis in a randomized placebo-controlled phase IIa studyBr. J. Dermatol.174(5),985-995(2016)
