LFM-A13
Cat. No.：YN340201
| 产品名称: | LFM-A13 |
| CAS No.: | 244240-24-2 |
| Chemical Name: | 2Z-cyano-N-(2,5-dibromophenyl)3-hydroxy-2-butenamide |
| Synonyms: | 2-Butenamide,2-cyano-N-(2,5-dibromophenyl)-3-hydroxy-, (2Z)-;2-cyano-N-(2,5-dibromophenyl)-3-oxobutanamide;LFM-A13;(2Z)-dehydrocitral;(2Z)-N-(2,5-dibromophenyl)-2-cyano-3-hydroxybut-2-enamide;(2Z,4E)-3,7-dimethyl-2,4,6-octatrienal;(2Z,4E)-3,7-dimethyl-oct |
| 分子量: | 360.00 |
| 分子式: | C₁₁H₈Br₂N₂O₂ |
| SMILES: | BrC1=C(NC(/C(C#N)=C(C)\O)=O)C=C(Br)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LFM-A13 是一种有效的BTK，JAK2，PLK抑制剂，可抑制 BTK，Plx1 和 PLK3 的活性，IC50分别为 2.5 μM，10 μM 和 61 μM。 |
| IC50和靶点: | [{name:"Plx1:10 μM (IC50)"},{name: "PLK3:61 μM (IC50)"},{name: "BRK:267 μM (IC50)"},{name: "BMX:281 μM (IC50)"},{name: "FYN:240 μM (IC50)"},{name: "Hepatocyte growth factor receptor kinase (Met):215 μM (IC50)"},{name: "BTK:2.5 μM (IC50)"}] |
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| Solvent & Solubility: |
Vassilev, A., Ozer, Z., Navara, C., et al.Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complexJ. Biol. Chem.274(3),1646-1656(1999)
Mahajan, S., Ghosh, S., Sudbeck, E.A., et al.Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK), LFM-A13 [α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide]J. Biol. Chem.274(14),9587-9599(1999)
Uckun, F.M., Dibirdik, I., Qazi, S., et al.Anti-breast cancer activity of LFM-A13, a potent inhibitor of polo-like kinase (PLK)Bioorg. Med. Chem.15(2),800-814(2007)
