Peficitinib
Cat. No.：YN340218
CAS No. ：944118-01-8
| 产品名称: | Peficitinib |
| CAS No.: | 944118-01-8 |
| Chemical Name: | 4-[(5-hydroxytricyclo[3.3.1.13,7]dec-2-yl)amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, stereoisomer |
| Synonyms: | ASP015K; JNJ-54781532 |
| 分子量: | 326.39 |
| 分子式: | C₁₈H₂₂N₄O₂ |
| SMILES: | O[C@](C[C@@H]1C[C@H]2C3)(C2)C[C@@H]3[C@H]1NC4=C5C(NC=C5)=NC=C4C(N)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Peficitinib 是一种可口服的JAK抑制剂，对 JAK1，JAK2，JAK3 和 Tyk2 的IC50值分别为 3.9，5.0，0.7 和 4.8 nM。 |
| IC50和靶点: | [{name:"JAK3:0.7 nM (IC50)"},{name: "JAK1:3.9 nM (IC50)"},{name: "Tyk2:4.8 nM (IC50)"},{name: "JAK2:5 nM (IC50)"}] |
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| Solvent & Solubility: |
Norman, P.Selective JAK inhibitors in development for rheumatoid arthritisExpert Opin. Investig. Drugs23(8),1067-1077(2014)
Ito, M., Yamazaki, S., Yamagami, K., et al.A novel JAK inhibitor, peficitinib, demonstrates potent efficacy in a rat adjuvant-induced arthritis modelJ. Pharmacol. Sci.133(1),25-33(2017)
