Brevilin A
Cat. No.：YN340278
| 产品名称: | Brevilin A |
| CAS No.: | 16503-32-5 |
| Chemical Name: | (2Z)-2-methyl-2-butenoic acid, 2,3S,3aR,4S,4aR,5,7aR,8R,9,9aR-decahydro-3,4a,8-trimethyl-2,5-dioxoazuleno[6,5-b]furan-4-yl ester |
| Synonyms: | 6-O-Angeloylplenolina |
| 分子量: | 346.42 |
| 分子式: | C₂₀H₂₆O₅ |
| SMILES: | C/C=C(C)\C(O[C@H]1[C@@]([C@@H]2C)([H])[C@@](OC2=O)([H])C[C@@H](C)[C@@]3([H])[C@]1(C(C=C3)=O)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Brevilin A 是一种从Centipeda minima中分离的倍半萜内酯，具有抗癌活性。Brevilin A 是一种选择性的JAK-STAT信号通路抑制剂，通过减弱 JAK 信号和 阻塞 STAT3 信号起作用。Brevilin A 通过线粒体途径和 PI3K/AKT/mTOR 失活诱导结肠腺癌细胞 CT26 的凋亡和自噬。 |
| IC50和靶点: | [{name:"STAT3:10.6 μM (IC50)"}] |
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You, P., Wu, H., Deng, M., et al.Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivationBiomed. Pharmacother.98,619-625(2018)
Chen, X., Du, Y., Nan, J.X., et al.Brevilin A, a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cellsPLoS One8(5),e63697(2013)
