BI-78D3
Cat. No.：YN350032
CAS No. ：883065-90-5
| 产品名称: | BI-78D3 |
| CAS No.: | 883065-90-5 |
| Chemical Name: | 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one |
| Synonyms: | 4-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-3-((5-nitrothiazol-2-yl)thio)-1H-1,2,4-triazol-5(4H)-one;4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-2,4-DIHYDRO-5-[(5-NITRO-2-THIAZOLYL)THIO]-3H-1,2,4-TRIAZOL-3-ONE;4-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[(5-nitro-1,3-thi |
| 分子量: | 379.37 |
| 分子式: | C₁₃H₉N₅O₅S₂ |
| SMILES: | O=C1N(C2=CC=C(OCCO3)C3=C2)C(SC4=NC=C([N+]([O-])=O)S4)=NN1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BI-78D3 是一种底物竞争性的JNK抑制剂，抑制 JNK 激酶活性，IC50为 280 nM。 |
| IC50和靶点: | [{name:"JNK:280 nM (IC50)"}] |
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| Solvent & Solubility: |
Stebbins, J.L., De, S.K., Machleidt, T., et al.Identification of a new JNK inhibitor targeting the JNK-JIP interaction siteProc. Natl. Acad. Sci. USA105(43),16809-16813(2008)
Strittmatter, F., Walther, S., Gratzke, C., et al.Inhibition of adrenergic human prostate smooth muscle contraction by the inhibitors of c-Jun N-terminal kinase, SP600125 and BI-78D3Br. J. Pharmacol.166(6),1926-1935(2012)
