JNK Inhibitor VIII
Cat. No.：YN350051
| 产品名称: | JNK Inhibitor VIII |
| CAS No.: | 894804-07-0 |
| Chemical Name: | N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-benzeneacetamide |
| Synonyms: | TCS JNK 6o |
| 分子量: | 356.38 |
| 分子式: | C₁₈H₂₀N₄O₄ |
| SMILES: | N#CC1=C(N=C(NC(CC2=C(C=CC(OC)=C2)OC)=O)C=C1N)OCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNK Inhibitor VIII (TCS JNK 6o) 是 c-Jun N-末端激酶(JNK-1, -2, -3)抑制剂，抑制 JNK-1、JNK-2、JNK-3 的Ki值分别为 2 nM、4 nM、52 nM，对 JNK-1、JNK-2 的IC50值分别是 45 nM 和 160 nM。 |
| IC50和靶点: | [{name:"JNK1:2 nM (Ki)"},{name: "JNK1:45 nM (IC50)"},{name: "JNK2:4 nM (Ki)"},{name: "JNK2:160 nM (IC50)"},{name: "JNK3:52 nM (Ki)"}] |
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Szczepankiewicz, B.G., Kosogof, C., Nelson, L.T., et al.Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activityJ. Med. Chem.49(12),3563-3580(2006)
Guha, I., Slamova, I., Chun, S., et al.The effects of short-term JNK inhibition on the survival and growth of aged sympathetic neuronsNeurobiol. Aging46,138-148(2016)
Lee, S., Lee, E.-K., Kang, D.H., et al.Glutathione peroxidase-1 regulates ASK1-dependent apoptosis via interaction with TRAF2 in RIPK3-negative cancer cellsExp. Mol. Med.53(6),1080-1091(2021)
