WHI-P258
Cat. No.：YN350056
CAS No. ：21561-09-1
| 产品名称: | WHI-P258 |
| CAS No.: | 21561-09-1 |
| Chemical Name: | 6,7-dimethoxy-N-phenyl-4-quinazolinamine |
| Synonyms: | JAK3 Inhibitor Negative Control,WHIP258,WHI P258 |
| 分子量: | 281.31 |
| 分子式: | C₁₆H₁₅N₃O₂ |
| SMILES: | COC1=CC2=NC=NC(NC3=CC=CC=C3)=C2C=C1OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WHI-P258 是一种喹唑啉化合物，结合到JAK3的活性位点，Ki约为 72 µM。WHI-P258 甚至在 100 μM 时不会抑制 JAK3 并不会影响凝血酶诱导的血小板聚集。 |
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Sudbeck, E.A., Liu, X.P., Narla, R.K., et al.Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agentsClin. Cancer Res.5(6),1569-1582(1999)
Yakota, S.-i., Yokosawa, N., Okabayashi, T., et al.Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 confers efficient viral replicationVirology338(1),173-181(2005)
Tibbles, H.E., Vassilev, A., Wendorf, H., et al.Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregationJ. Biol. Chem.276(21),17815-17822(2001)
