SP600125
Cat. No.：YN350095
CAS No. ：129-56-6
| 产品名称: | SP600125 |
| CAS No.: | 129-56-6 |
| Chemical Name: | anthra[1,9-cd]pyrazol-6(2H)-one |
| Synonyms: | Nsc75890 |
| 分子量: | 220.23 |
| 分子式: | C₁₄H₈N₂O |
| SMILES: | O=C1C2=C3C(NN=C3C4=C1C=CC=C4)=CC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SP600125 是一种口服有效的，可逆的，ATP竞争性的JNK抑制剂，抑制JNK1，JNK2和JNK3的IC50分别为 40，40，90 nM。SP600125 是一种有效的铁死亡 (ferroptosis) 抑制剂。SP600125 抑制自噬 (autophagy)，诱导凋亡 (apoptosis)。 |
| IC50和靶点: | [{name:"JNK1:40 nM (IC50)"},{name: "JNK2:40 nM (IC50)"},{name: "JNK3:90 nM (IC50)'}, 'Autophagy'] |
| In Vitro: | |
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| Solvent & Solubility: |
Bennett, B.L., Sasaki, D.T., Murray, B.W., et al.SP600125, an anthrapyrazolone inhibitor of jun N-terminal kinaseProc. Natl. Acad. Sci. USA98(24),13681-13686(2001)
Khan, M.A., Farahvash, A., Douda, D.N., et al.JNK activation turns on LPS- and gram-negative bacteria-induced NADPH oxidase-dependent suicidal NETosisSci. Rep.7(1),3409(2017)
Guan, Q.-H., Pei, D.-S., Zhang, Q.-G., et al.The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathwaysBrain Res.1035(1),51-59(2005)
