JNK-IN-8
Cat. No.：YN350135
| 产品名称: | JNK-IN-8 |
| CAS No.: | 1410880-22-6 |
| Chemical Name: | 3-[[4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide |
| Synonyms: | JNK Inhibitor XVI |
| 分子量: | 507.59 |
| 分子式: | C₂₉H₂₉N₇O₂ |
| SMILES: | CC1=CC(NC(C2=CC=CC(NC(/C=C/CN(C)C)=O)=C2)=O)=CC=C1NC3=NC=CC(C4=CN=CC=C4)=N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JNK-IN-8 (JNK Inhibitor XVI) 是一种有效的JNK抑制剂，抑制JNK1，JNK2和JNK3，IC50分别为 4.7 nM，18.7 nM 和 1 nM。 |
| IC50和靶点: | [{name:"JNK3:1 nM (IC50)"},{name: "JNK1:4.7 nM (IC50)"},{name: "JNK2:18.7 nM (IC50)"}] |
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Zhang, T., Inesta-Vaquero, F., Niepel, M., et al.Discovery of potent and selective covalent inhibitors of JNKChem. Biol.19(1),140-154(2012)
Li, Q., Song, X.m., Ji, Y.y., et al.The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitroBiochem. Biophys. Res. Commun.440(4),701-706(2013)
Fallahi-Sichani, M., Moerke, N.J., Niepel, M., et al.Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosisMol. Syst. Biol.11(3),797(2015)
