Tomatidine hydrochloride
Cat. No.：YN350241
CAS No. ：6192-62-7
| 产品名称: | Tomatidine hydrochloride |
| CAS No.: | 6192-62-7 |
| Chemical Name: | (3β,5α,22β,25S)-spirosolan-3-ol, monohydrochloride |
| Synonyms: | 盐酸番茄碱 |
| 分子量: | 452.11 |
| 分子式: | C₂₇H₄₆ClNO₂ |
| SMILES: | [H][C@]1(O[C@]2(NC[C@@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC[C@@]6([H])C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H].Cl[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tomatidine hydrochloride 通过阻断NF-κB和JNK信号发挥抗炎作用。Tomatidine hydrochloride 激活哺乳动物细胞或秀丽隐杆线虫中的自噬 (autophagy)。 |
| IC50和靶点: | |
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Chiu, F.L., and Lin, J.K.Tomatidine inhibits iNOS and COX-2 through suppression of NF-κB and JNK pathways in LPS-stimulated mouse macrophagesFEBS Lett.582(16),2407-2412(2008)
Kornhuber, J., Muehlbacher, M., Trapp, S., et al.Identification of novel functional inhibitors of acid sphingomyelinasePLoS One6(8),1-13(2011)
Mitchell, G., Gattuso, M., Grondin, G., et al.Tomatidine inhibits replication of Staphylococcus aureus small-colony variants in cystic fibrosis airway epithelial cellsAntimicrob. Agents Chemother.55(5),1937-1945(2011)
Dyle, M.C., Ebert, S.M., Cook, D.P., et al.Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophyJ. Biol. Chem.289(21),14913-14924(2014)
Zhao, C., Chen, A., Jamieson, C.H., et al.Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemiaNature458(7239),776-779(2009)
