APTO-253
Cat. No.：YN350177
CAS No. ：916151-99-0
| 产品名称: | APTO-253 |
| CAS No.: | 916151-99-0 |
| Chemical Name: | 2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline |
| Synonyms: | LOR-253; LT-253 |
| 分子量: | 367.38 |
| 分子式: | C₂₂H₁₄FN₅ |
| SMILES: | CC(N1)=C(C(N2)=NC3=C2C4=CC=CN=C4C5=NC=CC=C53)C6=C1C=CC(F)=C6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | APTO-253 是一种小分子，可抑制c-Myc表达，稳定 G-四链体 DNA 并诱导急性髓样白血病细胞的细胞周期停滞和凋亡。APTO-253 通过诱导 Kruppel-like factor 4(KLF4)抑癌因子介导抗癌活性。 |
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Nakajima, W., Miyazaki, K., Asano, Y., et al.Krüppel-like factor 4 and its activator APTO-253 induce NOXA-mediated, p53-independent apoptosis in triple-negative breast cancer cellsGenes (Basel)12(4),539(2021)
Local, A., Zhang, H., Benbatoul, K.D., et al.APTO-253 stabilizes G-quadruplex DNA, inhibits MYC expression, and induces DNA damage in acute myeloid leukemia cellsMol. Cancer Ther.17(6),1177-1186(2018)
Yang, X., Mathis, B.J., Huang, Y., et al.KLF4 promotes diabetic chronic wound healing by suppressing Th17 cell differentiation in an MDSC-dependent mannerJ. Diabetes Res.,7945117(2021)
