Paprotrain
Cat. No.：YN290030
CAS No. ：57046-73-8
| 产品名称: | Paprotrain |
| CAS No.: | 57046-73-8 |
| Chemical Name: | αZ-(3-pyridinylmethylene)-1H-indole-3-acetonitrile |
| Synonyms: | (alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile |
| 分子量: | 245.28 |
| 分子式: | C₁₆H₁₁N₃ |
| SMILES: | N#C/C(C1=CNC2=CC=CC=C21)=C\C3=CN=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Paprotrain是可渗透细胞的kinesin MKLP-2的抑制剂，抑制 MKLP-2 的 ATPase 活性，IC50值为 1.35 μM，Ki值为 3.36 μM，同时对DYRK1A有中等的抑制作用，IC50值为 5.5 μM。 |
| IC50和靶点: | [{name:"MKLP-2:1.35 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Good, J.A.D., Skoufias, D.A., and Kozielski, F.Elucidating the functionality of kinesins: An overview of small molecule inhibitorsSemin. Cell Dev. Biol.22(9),935-945(2011)
Tcherniuk, S., Skoufias, D.A., Labriere, C., et al.Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitorAngew. Chem. Int. Ed. Engl.49,8228-8231(2010)
