AZ82
Cat. No.：YN290179
CAS No. ：1449578-65-7
| 产品名称: | AZ82 |
| CAS No.: | 1449578-65-7 |
| Chemical Name: | αR-[[(5-methyl-4-propyl-2-thienyl)carbonyl]amino]-N-(3R)-3-pyrrolidinyl-6-[3-(trifluoromethoxy)phenyl]-3-pyridinepropanamide |
| Synonyms: | |
| 分子量: | 560.63 |
| 分子式: | C₂₈H₃₁F₃N₄O₃S |
| SMILES: | O=C(C1=CC(CCC)=C(C)S1)N[C@H](CC2=CC=C(C3=CC=CC(OC(F)(F)F)=C3)N=C2)C(N[C@H]4CNCC4)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZ82 是一种驱动蛋白样蛋白 KIFC1(HSET/KIFC1)的选择性抑制剂，其Ki值和IC50值分别为 43 nM 和 300 nM。 |
| IC50和靶点: | [{name:"HSET/KIFC1:300 nM (IC50)"},{name: "HSET/KIFC1:43 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Godinho, S.A., and Pellman, D.Causes and consequences of centrosome abnormalities in cancerPhilos. Trans. R. Soc. Lond. B Biol. Sci.369(1650),20130467(2014)
Wu, J., Mikule, K., Wang, W., et al.Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1ACS Chem. Biol.8(10),2201-2208(2013)
