EMD534085
Cat. No.：YN290326
CAS No. ：858668-07-2
| 产品名称: | EMD534085 |
| CAS No.: | 858668-07-2 |
| Chemical Name: | N-[2-(dimethylamino)ethyl]-N′-[[(2R,4aS,5R,10bS)-3,4,4a,5,6,10b-hexahydro-5-phenyl-9-(trifluoromethyl)-2H-pyrano[3,2-c]quinolin-2-yl]methyl]-urea |
| Synonyms: | EMD534085; EMD-534085; EMD 534085. |
| 分子量: | 476.53 |
| 分子式: | C₂₅H₃₁F₃N₄O₂ |
| SMILES: | O=C(NC[C@H]1CC[C@@]2([H])[C@H](C3=CC=CC=C3)NC4=C(C=C(C(F)(F)F)C=C4)[C@@]2([H])O1)NCCN(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EMD534085是有效选择性的有丝分裂驱动蛋白-5 (kinesin-5)的抑制剂，IC50值为8 nM。 |
| IC50和靶点: | [{name:"Kinesin-5:8 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Schiemann, K., Finsinger, D., Zenke, F., et al.The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5Bioorg. Med. Chem. Lett.20(5),1491-1495(2010)
Tang, Y., Orth, J.D., Xie, T., et al.Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cellsCancer Lett.310(1),15-24(2011)
