Filanesib
Cat. No.：YN290336
CAS No. ：885060-09-3
| 产品名称: | Filanesib |
| CAS No.: | 885060-09-3 |
| Chemical Name: | (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide |
| Synonyms: | ARRY-520 |
| 分子量: | 420.48 |
| 分子式: | C₂₀H₂₂F₂N₄O₂S |
| SMILES: | O=C(N1[C@@](C2=CC=CC=C2)(CCCN)SC(C3=CC(F)=CC=C3F)=N1)N(OC)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Filanesib (ARRY-520) 是一种选择性的纺锤体驱动蛋白 (KSP) 抑制剂，对人 KSP 作用的IC50值为 6 nM。Filanesib 在体外能诱导自噬导致细胞死亡。Filanesib 具有高效的抗增生活性。 |
| IC50和靶点: | [{name:"KSP:6 nM (IC50)"}] |
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| Solvent & Solubility: |
Woessner, R., Tunquist, B., Lemieux, C., et al.ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor modelsAnticancer Res.29(11),4373-4380(2009)
Carter, B.Z., Mak, D.H., Woessner, R., et al.Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cellsLeukemia23(10),1755-1762(2009)
