Dimethylenastron
Cat. No.：YN290473
CAS No. ：863774-58-7
| 产品名称: | Dimethylenastron |
| CAS No.: | 863774-58-7 |
| Chemical Name: | 2,3,4,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone |
| Synonyms: | Eg5 Inhibitor III |
| 分子量: | 302.39 |
| 分子式: | C₁₆H₁₈N₂O₂S |
| SMILES: | O=C1C2=C(NC(NC2C3=CC=CC(O)=C3)=S)CC(C)(C)C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Dimethylenastron 是一种有效的驱动蛋白Eg5抑制剂，IC50值为 200 nM。 |
| IC50和靶点: | [{name:"Eg5:200 nM (IC50)"}] |
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| Solvent & Solubility: |
Gartner, M., Sunder-Plassmann, N., Seiler, J., et al.Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5Chembiochem6(7),1173-1177(2005)
Sun, X.-d., Shi, X.-j., Sun, X.-o., et al.Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5Acta Pharmacol. Sin.32(12),1543-1548(2011)
Exertier, P., Javerzat, S., Wang, B., et al.Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5.Oncotarget4(12),2302-2316(2013)
