TH-257
Cat. No.：YN290181
CAS No. ：2244678-29-1
| 产品名称: | TH-257 |
| CAS No.: | 2244678-29-1 |
| Chemical Name: | N-butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)-benzamide |
| Synonyms: | TH 257 |
| 分子量: | 422.54 |
| 分子式: | C₂₄H₂₆N₂O₃S |
| SMILES: | O=C(N(CCCC)CC1=CC=CC=C1)C2=CC=C(S(=O)(NC3=CC=CC=C3)=O)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TH-257 是一种有效的LIMK1和LIMK2抑制剂，对LIMK1和LIMK2的IC50值分别为 84 nM 和 39 nM，是LIMK1和LIMK2的化学探针。TH-257 是一种变构抑制剂，靶向由 αC 和 DFG-out 构象诱导的结合口袋。TH257 具有极好的选择性，在 1 μM 浓度下未观察到针对更广泛的激酶组的显着活性。 |
| IC50和靶点: | [{name:"LIMK1:84 nM (IC50)"},{name: "LIMK2:39 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Manetti, F.Recent advances in the rational design and development of LIM kinase inhibitors are not enough to enter clinical trialsEur. J. Med. Chem.155,445-458(2018)
