BMS-3
Cat. No.：YN290429
CAS No. ：1338247-30-5
| 产品名称: | BMS-3 |
| CAS No.: | 1338247-30-5 |
| Chemical Name: | N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-cyclopropanecarboxamide |
| Synonyms: | BMS-3;N-[5-[2-(2,6-dichlorophenyl)-5-(difluoromethyl)pyrazol-3-yl]-1,3-thiazol-2-yl]cyclopropanecarboxamide;BMS3;N-[5-[1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-cyclopropanecarboxamide;N-(5-(1-(2,6-dichlorophenyl)-3-(difluoro |
| 分子量: | 429.27 |
| 分子式: | C₁₇H₁₂Cl₂F₂N₄OS |
| SMILES: | O=C(C1CC1)NC2=NC=C(C3=CC(C(F)F)=NN3C4=C(Cl)C=CC=C4Cl)S2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS-3 是一种高效的LIMK抑制剂，抑制LIMK1和LIMK2，IC50分别为 5 nM 和 6 nM。 |
| IC50和靶点: | [{name:"LIMK1:5 nM (IC50)"},{name: "LIMK2:6 nM (IC50)"}] |
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| Solvent & Solubility: |
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Li, X., Zhu, Y., Cao, Y., et al.LIM kinase activity is required for microtubule organising centre positioning in mouse oocyte meiosisReprod. Fertil. Dev.29(4),791-804(2016)
Romarowski, A., Battistone, M.A., La Spina, F.A., et al.PKA-dependent phosphorylation of LIMK1 and Cofilin is essential for mouse sperm acrosomal exocytosisDev. Biol.405(2),237-249(2015)
Sari-Hassoun, M., Clement, M.-J., Hamdi, I., et al.Cucurbitacin I elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-kinaseBiochem. Pharmacol.102,45-63(2016)
