BMS-5
Cat. No.：YN290430
CAS No. ：1338247-35-0
| 产品名称: | BMS-5 |
| CAS No.: | 1338247-35-0 |
| Chemical Name: | N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methyl-propanamide |
| Synonyms: | LIMKi 3 |
| 分子量: | 431.29 |
| 分子式: | C₁₇H₁₄Cl₂F₂N₄OS |
| SMILES: | CC(C)C(NC1=NC=C(C2=CC(C(F)F)=NN2C3=C(Cl)C=CC=C3Cl)S1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS-5 (LIMKi 3) 是一种高效的LIMK抑制剂，抑制LIMK1和LIMK2，IC50分别为 7 nM 和 8 nM。 |
| IC50和靶点: | [{name:"LIMK1:7 nM (IC50)"},{name: "LIMK2:8 nM (IC50)"}] |
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| Solvent & Solubility: |
Ross-Macdonald, P., de Silva, H., Guo, Q., et al.Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitorsMol. Cancer Ther.7(11),3490-3498(2008)
Li, X., Zhu, Y., Cao, Y., et al.LIM kinase activity is required for microtubule organising centre positioning in mouse oocyte meiosisReprod. Fertil. Dev.29(4),791-804(2016)
Romarowski, A., Battistone, M.A., La Spina, F.A., et al.PKA-dependent phosphorylation of LIMK1 and Cofilin is essential for mouse sperm acrosomal exocytosisDev. Biol.405(2),237-249(2015)
