BMS-986020
Cat. No.：YN320060
CAS No. ：1257213-50-5
| 产品名称: | BMS-986020 |
| CAS No.: | 1257213-50-5 |
| Chemical Name: | 1-[4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl][1,1'-biphenyl]-4-yl]-cyclopropanecarboxylic acid |
| Synonyms: | AM152, AP-3152 free acid |
| 分子量: | 482.53 |
| 分子式: | C₂₉H₂₆N₂O₅ |
| SMILES: | O=C(C1(C2=CC=C(C3=CC=C(C4=C(NC(O[C@@H](C5=CC=CC=C5)C)=O)C(C)=NO4)C=C3)C=C2)CC1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS-986020 是高亲和力溶血磷脂酸受体 1 (LPA1) 拮抗剂。BMS-986020 抑制胆汁酸和磷脂转运蛋白，抑制 BSEP，MRP4 和 MDR3，IC50值分别为 4.8 μM，6.2 μM 和 7.5 μM。BMS-986020 有潜力用于特发性肺纤维化 (IPF) 的研究。 |
| IC50和靶点: | |
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Cheng, P.T.W., Kaltenbach, R.F., III, Zhang, H., et al.Discovery of an oxycyclohexyl acid lysophosphatidic acid receptor 1 (LPA1) antagonist BMS-986278 for the treatment of pulmonary fibrotic diseasesJ. Med. Chem.64(21),15549-15581(2021)
Hutchinson, J.H., Seiders, T.J., Wang, B., et al.Polycyclic antagonists of lysophosphatidic acid receptors,(2010)
Sivaraman, L., Gill, M., Nelson, D.M., et al.Structure dependence and species sensitivity of in vivo hepatobiliary toxicity with lysophosphatidic acid receptor 1 (LPA1) antagonistsToxicol. Appl. Pharmacol.,115846(2021)
Gaire, B.P., Sapkota, A., and Choi, J.W.BMS-986020, a specific LPA1 antagonist, provides neuroprotection against ischemic stroke in miceAntioxidants (Basel)9(11),1097(2020)
