JTE-013
Cat. No.：YN320072
CAS No. ：383150-41-2
| 产品名称: | JTE-013 |
| CAS No.: | 383150-41-2 |
| Chemical Name: | N-(2,6-dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-hydrazinecarboxamide |
| Synonyms: | 1-(2,6-dichloropyridin-4-yl)-3-[(1,3-dimethyl-4-propan-2-ylpyrazolo[3,4-b]pyridin-6-yl)amino]urea;JTE-013;Jte 013;S1P2 Receptor Antagonist, JTE-013;1-(1,3-Dimethyl-4-isopropyl)-1H-pyrazolo[3,4-b]pyridin-6-yl)-4-(3,5-dichloro-4-pyridinyl)-semicarbazide;pyr |
| 分子量: | 408.29 |
| 分子式: | C₁₇H₁₉Cl₂N₇O |
| SMILES: | CC(C1=C2C(N(C)N=C2C)=NC(NNC(NC3=CC(Cl)=NC(Cl)=C3)=O)=C1)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | JTE-013 是一种有效且选择性的S1P2(鞘氨醇1-磷酸2) 拮抗剂。JTE-013 抑制放射性标记的 S1P 与人和大鼠 S1P2的特异性结合，IC50分别为 17 nM 和 22 nM。 |
| IC50和靶点: | |
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Pitman, M., Lewis, A.C., Davies, L.T., et al.The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolismSci. Rep.12(1),454(2022)
Osada, M., Yatomi, Y., Ohmori, T., et al.Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonistBiochem. Biophys. Res. Commun.299(3),483-487(2002)
Arikawa, K., Takuwa, N., Yamaguchi, H., et al.Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular rac activityJ. Biol. Chem.278(35),32841-32851(2003)
Xu, Q., Chen, J., Zhu, Y., et al.JTE-013 alleviates inflammatory injury and endothelial dysfunction induced by sepsis in vivo and in vitroJ. Surg. Res.265,323-332(2021)
