CYM-5541
Cat. No.：YN320144
CAS No. ：945128-26-7
| 产品名称: | CYM-5541 |
| CAS No.: | 945128-26-7 |
| Chemical Name: | N,N-dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide |
| Synonyms: | ML249 |
| 分子量: | 316.44 |
| 分子式: | C₁₉H₂₈N₂O₂ |
| SMILES: | O=C(C1=NOC(C2CC2)=C1)N(C3CCCCC3)C4CCCCC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CYM-5541 (ML249)是选择性的S1P3受体变构激动剂，EC50值在72至132 nM之间。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Choi, J.W., Lee, C.W., and Chun, J.Biological roles of lysophospholipid receptors revealed by genetic null mice: An updateBiochim. Biophys. Acta1781(9),531-539(2008)
Rosen, H., Stevens, R.C., Hanson, M., et al.Sphingosine-1-phosphate and its receptors: Structure, signaling, and influenceAnnu. Rev. Biochem.82,637-662(2013)
Guerrero, M., Poddutoori, R., Pinacho-Crisostomo, F., et al.Probe development efforts for an allosteric agonist of the sphingosine 1-phosphate receptor 3 (S1P3),1-13(2011)
Jo, E., Bhhatarai, B., Repetto, E., et al.Novel selective allosteric and bitopic ligands for the S1P3 receptorACS Chem. Biol.7(12),1975-1983(2012)
