CYM50308
Cat. No.：YN320365
| 产品名称: | CYM50308 |
| CAS No.: | 1345858-76-5 |
| Chemical Name: | (2Z,5Z)-5-[[1-(2,4-difluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]methylene]-2-[(2-methoxyethyl)imino]-3-methyl-4-thiazolidinone |
| Synonyms: | ML248 |
| 分子量: | 405.46 |
| 分子式: | C₂₀H₂₁F₂N₃O₂S |
| SMILES: | O=C1N(C)/C(S/C1=C\C2=C(C)N(C3=CC=C(F)C=C3F)C(C)=C2)=N/CCOC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CYM50308 (ML248) 是一种有效的，选择性和高亲和力的鞘氨醇-1-磷酸受体 4 (S1P4-R) 激动剂，EC50为 56 nM。CYM50308 对S1P4-R的选择性比 S1P5-R (EC50of 2100 nM) 高 37 倍。在浓度高达 25 μM 时，CYM50308 对 S1P1-R，S1P2-R 和 S1P3-R 没有活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Urbano, M., Guerrero, M., Velaparthi, S., et al.Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotypeBioorg. Med. Chem. Lett.21(22),6739-6745(2011)
