Sphingosine-1-phosphate
Cat. No.：YN320366
| 产品名称: | Sphingosine-1-phosphate |
| CAS No.: | 26993-30-6 |
| Chemical Name: | 2S-amino-4E-octadecene-1,3R-diol 1-(dihydrogen phosphate) |
| Synonyms: | S1P |
| 分子量: | 379.47 |
| 分子式: | C₁₈H₃₈NO₅P |
| SMILES: | N[C@@H](CO[P](O)(O)=O)[C@H](O)/C=C/CCCCCCCCCCCCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sphingosine-1-phosphate (S1P) 是 S1P1-5受体 (S1P1-5receptors) 的激动剂和 GPR3、GPR6、GPR12 的配体。Sphingosine-1-phosphate 是细胞内的第二信使，动员 Ca2+作为 G 蛋白偶联受体的细胞外配体。Sphingosine-1-phosphate 是由鞘磷脂 (HY-113498) 或其他膜磷脂生成的重要脂质介质。 |
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Sanchez, T., and Hla, T.Structural and functional characteristics of S1P receptorsJ. Cell. Biochem.92(5),913-922(2004)
van Koppen, C.J., zu Heringdorf, D.M., Laser, K.T., et al.Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphateJ. Biol. Chem.271(4),2082-2087(1996)
An, S., Bleu, T., and Zheng, Y.Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptorsMol. Pharmacol.55(5),787-794(1999)
Cartier, A., and Hla, T.Sphingosine 1-phosphate: Lipid signaling in pathology and therapyScience366(6463),(2019)
