Fingolimod
Cat. No.：YN320423
CAS No. ：162359-55-9
| 产品名称: | Fingolimod |
| CAS No.: | 162359-55-9 |
| Chemical Name: | 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol |
| Synonyms: | 芬戈莫德; FTY720 free base |
| 分子量: | 307.47 |
| 分子式: | C₁₉H₃₃NO₂ |
| SMILES: | OCC(CCC1=CC=C(CCCCCCCC)C=C1)(N)CO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fingolimod (FTY720 free base) 是一种 1-磷酸鞘氨醇 (sphingosine 1-phosphate，S1P) 拮抗剂，作用于 K562 和 NK 细胞，IC50为 0.033 nM。Fingolimod 还是一种pak1激活剂，免疫抑制剂。 |
| IC50和靶点: | [{name:"S1P:0.033 nM (IC50, in K562 and NK cells)'}, 'PAK1'] |
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Brinkmann, V., Pinschewer, D.D., Feng, L., et al.FTY720: Altered lymphocyte traffic results in allograft protectionTransplantation72(5),764-769(2001)
Brinkmann, V., Davis, M.D., Heise, C.E., et al.The immune modulator FTY720 targets sphingosine 1-phosphate receptorsJ. Biol. Chem.277(24),21453-21457(2002)
Matloubian, M., Lo, C.G., Cinamon, G., et al.Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1Nature427(6972),355-360(2004)
Honig, S.M., Fu, S., Mao, X., et al.FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodesJ. Clin. Invest.111(5),627-637(2003)
Payne, S.G., Oskeritizian, C.A., Griffiths, R., et al.The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptorsBlood109(3),1077-1085(2007)
