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Fingolimod hydrochloride

Cat. No.:YN320528

  • CAS No. :162359-56-0

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    • 参考文献
    • 产品名称: Fingolimod hydrochloride
      CAS No.: 162359-56-0
      Chemical Name: 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol, hydrochloride
      Synonyms:盐酸芬戈莫德; FTY720
      分子量:343.93
      分子式:C₁₉H₃₄ClNO₂
      SMILES:OCC(N)(CO)CCC1=CC=C(C=C1)CCCCCCCC.[H]Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Fingolimod hydrochloride (FTY720) 是鞘氨醇1-磷酸 (S1P) 拮抗剂,在 K562 和 NK 细胞中的IC50为 0.033 nM。Fingolimod hydrochloride 还是一种pak1激活剂。
      IC50和靶点: [{name:"S1P:0.033 nM (IC50, in K562 and NK cells)'}, 'PAK1']
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Brinkmann, V., Pinschewer, D.D., Feng, L., et al.FTY720: Altered lymphocyte traffic results in allograft protectionTransplantation72(5),764-769(2001)

      Brinkmann, V., Davis, M.D., Heise, C.E., et al.The immune modulator FTY720 targets sphingosine 1-phosphate receptorsJ. Biol. Chem.277(24),21453-21457(2002)

      Matloubian, M., Lo, C.G., Cinamon, G., et al.Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1Nature427(6972),355-360(2004)

      Honig, S.M., Fu, S., Mao, X., et al.FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodesJ. Clin. Invest.111(5),627-637(2003)

      Payne, S.G., Oskeritizian, C.A., Griffiths, R., et al.The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptorsBlood109(3),1077-1085(2007)

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