Ozanimod
Cat. No.：YN320570
CAS No. ：1306760-87-1
| 产品名称: | Ozanimod |
| CAS No.: | 1306760-87-1 |
| Chemical Name: | 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)-benzonitrile |
| Synonyms: | 奥扎莫德; RPC-1063 |
| 分子量: | 404.46 |
| 分子式: | C₂₃H₂₄N₄O₃ |
| SMILES: | N#CC1=CC(C2=NC(C3=CC=CC4=C3CC[C@@H]4NCCO)=NO2)=CC=C1OC(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ozanimod (RPC-1063) 是一种有效的选择性S1P1和S1P5受体激动剂，在[35S]-GTPγS 结合实验中，EC50分别为 410 pM 和 11 nM。 |
| IC50和靶点: | [{name:"S1PR1:1.03 nM (EC50)"},{name: "S1PR5:8.6 nM (EC50)"}] |
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| Solvent & Solubility: |
Scott, F.L., Clemons, B., Brooks, J., et al.Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1) and receptor-5 (S1P5) agonist with autoimmune disease-modifying activityBr. J. Pharmacol.173(11),1778-1792(2016)
