Ki16425
Cat. No.：YN320714
| 产品名称: | Ki16425 |
| CAS No.: | 355025-24-0 |
| Chemical Name: | 3-[[[4-[4-[[[1-(2-chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazoly]phenyl]methyl]thio]-propanoic acid |
| Synonyms: | Debio 0719 |
| 分子量: | 474.96 |
| 分子式: | C₂₃H₂₃ClN₂O₅S |
| SMILES: | ClC1=C(C=CC=C1)C(C)OC(NC2=C(ON=C2C)C3=CC=C(C=C3)CSCCC(O)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ki16425 (Debio 0719) 是一种亚型选择性，竞争性的 EDG 家族受体拮抗剂，对LPA1和LPA3的Ki值分别为 0.34 μM，0.93 μM。Ki16425 (Debio 0719) 降低LPA诱导的 p42/p44 MAPK 激活。Ki16425 还可抑制LPA诱导的 HEK293A 细胞中 YAP/TAZ 的去磷酸化。 |
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Choi, J.W., Lee, C.W., and Chun, J.Biological roles of lysophospholipid receptors revealed by genetic null mice: An updateBiochim. Biophys. Acta1781(9),531-539(2008)
Ohta, H., Sato, K., Murata, N., et al.Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptorsMol. Pharmacol.64(4),994-1005(2003)
Yamada, T., Sato, K., Komachi, M., et al.Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPAJ. Biol. Chem.279(8),6595-6605(2004)
