FTY720 (S)-Phosphate
Cat. No.：YN320971
| 产品名称: | FTY720 (S)-Phosphate |
| CAS No.: | 402616-26-6 |
| Chemical Name: | (2S)-amino-2-[2-(4-octylphenyl)ethyl]-1-(dihydrogen phosphate)-1,3-propanediol |
| Synonyms: | (S)-FTY720P; (S)-FTY720 phosphate |
| 分子量: | 387.45 |
| 分子式: | C₁₉H₃₄NO₅P |
| SMILES: | OC[C@](CCC1=CC=C(CCCCCCCC)C=C1)(N)COP(O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FTY720 (S)-Phosphate 是一种 S1P 受体 1 (S1PR1) 激动剂，可以用于急性肺损伤等急性炎症的研究。 |
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Brinkmann, V., Pinschewer, D.D., Feng, L., et al.FTY720: Altered lymphocyte traffic results in allograft protectionTransplantation72(5),764-769(2001)
Brinkmann, V., Davis, M.D., Heise, C.E., et al.The immune modulator FTY720 targets sphingosine 1-phosphate receptorsJ. Biol. Chem.277(24),21453-21457(2002)
Albert, R., Hinterding, K., Brinkmann, V., et al.Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomerJ. Med. Chem.48(16),5373-5377(2005)
Kiuchi, M., Adachi, K., Tomatsu, A., et al.Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphateBioorg. Med. Chem.13(2),425-432(2005)
Brinkmann, V.FTY720: Mechanism of action and potential benefit in organ transplantationYonsei Med. J.45(6),991-997(2004)
Honig, S.M., Fu, S., Mao, X., et al.FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodesJ. Clin. Invest.111(5),627-637(2003)
Payne, S.G., Oskeritizian, C.A., Griffiths, R., et al.The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptorsBlood109(3),1077-1085(2007)
