PF-543 Citrate
Cat. No.：YN320986
CAS No. ：1415562-83-2
| 产品名称: | PF-543 Citrate |
| CAS No.: | 1415562-83-2 |
| Chemical Name: | |
| Synonyms: | Sphingosine Kinase 1 Inhibitor II Citrate |
| 分子量: | 657.73 |
| 分子式: | C₃₃H₃₉NO₁₁S |
| SMILES: | OC(C(O)=O)(CC(O)=O)CC(O)=O.O=S(C1=CC=CC=C1)(CC2=CC(C)=CC(OCC3=CC=C(CN4[C@@H](CO)CCC4)C=C3)=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) 是一种有效，选择性，可逆和鞘氨醇竞争性SPHK1抑制剂，IC50为 2 nM，Ki为 3.6 nM。PF-543 Citrate 对SPHK1的选择性是 SPHK2 的 100 倍以上。PF-543 Citrate 还是有效的全血中 1-磷酸鞘氨醇 (S1P) 形成的有效抑制剂，IC50为 26.7 nM。PF-543 Citrate 诱导细胞凋亡，坏死和自噬。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
