Cenerimod
Cat. No.：YN321166
CAS No. ：1262414-04-9
| 产品名称: | Cenerimod |
| CAS No.: | 1262414-04-9 |
| Chemical Name: | (2S)-3-[4-[5-(2-cyclopentyl-6-methoxy-4-pyridinyl)-1,2,4-oxadiazol-3-yl]-2-ethyl-6-methylphenoxy]-1,2-propanediol |
| Synonyms: | ACT-334441 |
| 分子量: | 453.53 |
| 分子式: | C₂₅H₃₁N₃O₅ |
| SMILES: | OC[C@H](O)COC1=C(C)C=C(C2=NOC(C3=CC(C4CCCC4)=NC(OC)=C3)=N2)C=C1CC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cenerimod (ACT-334441) 是高效有口服活性的鞘氨醇1-磷酸1 (S1P1) 受体激动剂, 来自专利专利WO 2016184939 A1和WO 2011007324 A1，化合物实例1。EC50值为2.7 nM。 |
| IC50和靶点: | [{name:"S1PR1:1 nM (EC50)"},{name: "S1PR5:36 nM (EC50)"},{name: "S1PR5:228 nM (EC50)"},{name: "S1PR4:2134 nM (EC50)"}] |
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Piali, L., Birker-Robaczewska, M., Lescop, C., et al.Cenerimod, a novel selective S1P1 receptor modulator with unique signaling propertiesPharmacol. Res. Perspec.5(6),e00370(2017)
Kano, M., Kobayashi, T., Date, M., et al.Attenuation of murine sclerodermatous models by the selective S1P1 receptor modulator cenerimodSci. Rep.9(1),658(2019)
