SEW2871
Cat. No.：YN322098
| 产品名称: | SEW2871 |
| CAS No.: | 256414-75-2 |
| Chemical Name: | 5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole |
| Synonyms: | SEW2871 |
| 分子量: | 440.36 |
| 分子式: | C₂₀H₁₀F₆N₂OS |
| SMILES: | FC(C1=CC(C2=NOC(C3=CC(C4=CC=CC=C4)=C(C(F)(F)F)S3)=N2)=CC=C1)(F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SEW2871 是高度选择性的，具有口服活性的S1P1激动剂，EC50为 13.8 nM。SEW2871 激活 ERK，Akt 和 Rac 信号通路，并诱导 S1P1 内在化和再循环。SEW2871 减少血液中的淋巴细胞数量，可用于糖尿病，阿尔茨海默氏病，肝纤维化和炎症相关研究。 |
| IC50和靶点: | [{name:"S1PR1:13.8 nM (EC50)"}] |
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| Solvent & Solubility: |
Kluk, M.J., and Hla, T.Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptorsBiochim. Biophys. Acta1582(1-3),72-80(2002)
Sanna, M.G., Liao, J., Jo, E., et al.Sphingosine 1-phosphate (S1P) receptor subtypes SIP1 and SIP3, respectively, regulate lymphocyte recirculation and heart rateJ. Biol. Chem.279(14),13839-13848(2004)
