MLi-2
Cat. No.：YN280003
CAS No. ：1627091-47-7
| 产品名称: | MLi-2 |
| CAS No.: | 1627091-47-7 |
| Chemical Name: | rel-3-[6-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-pyrimidinyl]-5-[(1-methylcyclopropyl)oxy]-1H-indazole |
| Synonyms: | MLi2; Mli 2 |
| 分子量: | 379.46 |
| 分子式: | C₂₁H₂₅N₅O₂ |
| SMILES: | C[C@@](C1)([H])O[C@](C)([H])CN1C2=CC(C3=NNC4=CC=C(OC5(C)CC5)C=C43)=NC=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MLi-2 是一种具有口服活性的，高选择性LRRK2抑制剂，IC50为 0.76 nM。MLi-2 具有用于帕金森氏病的潜力。 |
| IC50和靶点: | |
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Fell, M.J., Mirescu, C., Basu, K., et al.MLi-2, a potent, selective, and centrally active compound for exploring the therapeutic potential and safety of LRRK2 kinase inhibitionJ. Pharmacol. Exp. Ther.355(3),397-409(2015)
Ysselstein, D., Nguyen, M., Young, T.J., et al.LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patientsNat. Commun.10(1),5570(2019)
