GNE-9605
Cat. No.：YN280039
CAS No. ：1536200-31-3
| 产品名称: | GNE-9605 |
| CAS No.: | 1536200-31-3 |
| Chemical Name: | rel-N2-[5-chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-2,4-pyrimidinediamine |
| Synonyms: | GNE9605;2,4-Pyrimidinediamine, N2-[5-chloro-1-[(3R,4R)-3-fluoro-1-(3-oxetanyl)-4-piperidinyl]-1H-pyrazol-4-yl]-N4-methyl-5-(trifluoromethyl)-, rel-;GNE-9605 |
| 分子量: | 449.83 |
| 分子式: | C₁₇H₂₀ClF₄N₇O |
| SMILES: | FC(C1=CN=C(NC2=C(Cl)N([C@@H]3[C@@H](F)CN(C4COC4)CC3)N=C2)N=C1NC)(F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GNE 9605是一个高效，选择性和能脑渗透的LRRK2抑制剂，IC50为19 nM。 |
| IC50和靶点: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Estrada, A.A., Chan, B.K., Baker-Glenn, C., et al.Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitorsJ. Med. Chem.57(3),921-936(2014)
