GNE0877
Cat. No.：YN280086
CAS No. ：1374828-69-9
| 产品名称: | GNE0877 |
| CAS No.: | 1374828-69-9 |
| Chemical Name: | α,α,3-trimethyl-4-[[4-(methylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1H-pyrazole-1-acetonitrile |
| Synonyms: | GNE-0877,GNE 0877 |
| 分子量: | 339.32 |
| 分子式: | C₁₄H₁₆F₃N₇ |
| SMILES: | CC1=NN(C(C)(C)C#N)C=C1NC2=NC=C(C(F)(F)F)C(NC)=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GNE0877是高活性、选择性、可通透脑屏障的LRRK2抑制剂，IC50为3 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Estrada, A.A., Chan, B.K., Baker-Glenn, C., et al.Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitorsJ. Med. Chem.57(3),921-936(2014)
