CZC-25146
Cat. No.：YN280087
CAS No. ：1191911-26-8
| 产品名称: | CZC-25146 |
| CAS No.: | 1191911-26-8 |
| Chemical Name: | N-[2-[[5-fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-methanesulfonamide |
| Synonyms: | CHEMBL2397014 |
| 分子量: | 488.54 |
| 分子式: | C₂₂H₂₅FN₆O₄S |
| SMILES: | CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2F)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CZC-25146是代谢稳定性的LRRK2抑制剂，对野生型LRRK2和G2019S LRRK2的IC50分别为4.76 nM和6.87 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ramsden, N.G., Perrin, J., Ren, Z., et al.Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neuronsACS Chem Biol.6(10),1021-1028(2011)
