CZC-54252
Cat. No.：YN280114
CAS No. ：1191911-27-9
| 产品名称: | CZC-54252 |
| CAS No.: | 1191911-27-9 |
| Chemical Name: | N-[2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-methanesulfonamide |
| Synonyms: | CZC 54252,CZC54252 |
| 分子量: | 504.99 |
| 分子式: | C₂₂H₂₅ClN₆O₄S |
| SMILES: | CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Cl)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CZC-54252 是一种有效的选择性LRRK2抑制剂，对野生型和G2019S LRRK2的IC50分别为 1.28 nM 和 1.85 nM。CZC-54252 减弱由 G2019S LRRK2 诱导的人神经元损伤 ，EC50约为 1 nM，具有神经保护活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Kramer, T.T., Monte, F.L., Göring, S., et al.Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease modelsACS Chem. Neurosci.3(3),151-160(2012)
Ramsden, N.G., Perrin, J., Ren, Z., et al.Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neuronsACS Chem Biol.6(10),1021-1028(2011)
