LY223982
Cat. No.：YN320460
CAS No. ：117423-74-2
| 产品名称: | LY223982 |
| CAS No.: | 117423-74-2 |
| Chemical Name: | 5-(3-carboxybenzoyl)-2-[[(5E)-6-(4-methoxyphenyl)-5-hexenyl]oxy]-benzenepropanoic acid |
| Synonyms: | CGS23131; SKF107324 |
| 分子量: | 502.56 |
| 分子式: | C₃₀H₃₀O₇ |
| SMILES: | O=C(O)CCC1=CC(C(C2=CC=CC(C(O)=O)=C2)=O)=CC=C1OCCCC/C=C/C3=CC=C(OC)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY223982 是一种有效的，特异性的白三烯 B4 受体 (leukotriene B4 receptor)抑制剂，能够有效抑制 [3H]LTB4 与 LTB4 受体结合，IC50值为 13.2 nM。 |
| IC50和靶点: | [{name:"LTB4:13.2 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Gapinski, D.M., Mallett, B.E., Froelich, L.L., et al.Benzophenone dicarboxylic acid antagonists of leukotriene B4. 2. Structure-activity relationships of the lipophilic side chainJ. Med. Chem.33(10),2807-2813(1990)
Jackson, W.T., Boyd, R.J., Froelich, L.L., et al.Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982J. Pharmacol. Exp. Ther.263(3),1009-1014(1992)
Yokomizo, T., Kato, K., Hagiya, H., et al.Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2J. Biol. Chem.276(15),12454-12459(2001)
