Montelukast sodium
Cat. No.：YN320723
| 产品名称: | Montelukast sodium |
| CAS No.: | 151767-02-1 |
| Chemical Name: | 1-[[[(1R)-1-[3-(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]-methyl]-cyclopropaneacetic acid, monosodium salt |
| Synonyms: | 孟鲁司特钠; MK0476 |
| 分子量: | 608.17 |
| 分子式: | C₃₅H₃₅ClNNaO₃S |
| SMILES: | ClC1=CC2=C(C=C1)C=CC(/C=C/C3=CC([C@H](SCC4(CC(O[Na])=O)CC4)CCC5=CC=CC=C5C(C)(O)C)=CC=C3)=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Montelukast sodium 是一种有效的、选择性和具有口服活性的半胱氨酸白三烯受体1 (Cysltr1)拮抗剂。Montelukast sodium 可用于研究预防哮喘和肝损伤。Montelukast sodium 在肠缺血-再灌注损伤中也具有抗氧化作用，还可以减少心脏损伤。 |
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Sarau, H.M., Ames, R.S., Chambers, J., et al.Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptorMol. Pharmacol.56(3),657-663(1999)
Heise, C.E., O'Dowd, B.F., Figueroa, D.J., et al.Characterization of the human cysteinyl leukotriene 2 receptorJ. Biol. Chem.275(39),30531-30536(2000)
Cabré, F., Carabaza, A., García, A.M., et al.Pharmacological profile of MEN91507, a new CysLT1 receptor antagonistEur. J. Pharmacol.451(3),317-326(2002)
Eum, S.Y., Maghni, K., Hamid, Q., et al.Involvement of the cysteinyl-leukotrienes in allergen-induced airway eosinophilia and hyperresponsiveness in the mouseAm. J. Respir. Cell Mol. Biol.28(1),25-32(2003)
