Etalocib
Cat. No.：YN320769
| 产品名称: | Etalocib |
| CAS No.: | 161172-51-6 |
| Chemical Name: | 2-[3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]4-yl)oxy]propoxy]-2-propylphenoxy]-benzoic acid |
| Synonyms: | LY293111; VML 295 |
| 分子量: | 544.61 |
| 分子式: | C₃₃H₃₃FO₆ |
| SMILES: | O=C(O)C1=CC=CC=C1OC2=CC=CC(OCCCOC3=C(CC)C=C(C4=CC=C(F)C=C4)C(O)=C3)=C2CCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Etalocib (LY293111) 是具有口服活性的白三烯(LTB4)受体的拮抗剂，抑制 [3H]LTB4结合的Ki值为 25 nM. Etalocib (LY293111) 抑制LTB4诱导的钙动员的lC50值为 20 nM。Etalocib (LY293111) 可诱导凋亡。 |
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Jackson, W.T., Froelich, L.L., Boyd, R.J., et al.Pharmacologic actions of the second-generation leukotriene B4 receptor antagonist LY293111: In vitro studiesJ. Pharmacol. Exp. Ther.288(1),286-294(1999)
Tong, W.G., Ding, X.Z., Hennig, R., et al.Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cellsClin. Cancer Res.8,3232-3242(2002)
