LY255283
Cat. No.：YN321027
CAS No. ：117690-79-6
| 产品名称: | LY255283 |
| CAS No.: | 117690-79-6 |
| Chemical Name: | 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]-ethanone |
| Synonyms: | LY 255283 |
| 分子量: | 360.45 |
| 分子式: | C₁₉H₂₈N₄O₃ |
| SMILES: | CC(C1=CC(CC)=C(OCCCCCC(C2=NNN=N2)(C)C)C=C1O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY255283 是LTB4受体(BLT2)的拮抗剂，其抑制 [3H]LTB4结合到豚鼠肺膜的IC50值约为 100 nM。 |
| IC50和靶点: | [{name:"LTB4:~100 nM (IC50, LTB4 binds to guinea pig lung membranes)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Richards, I.M., Sun, F.F., Taylor, B.M., et al.Contribution of leukotriene B4 to airway inflammation and the effect of antagonistsAnn. N. Y. Acad. Sci.629,274-287(1991)
Taylor, B.M., Crittenden, N.J., Bruden, M.N., et al.Biological activity of leukotriene B4 analogs: Inhibition of guinea pig eosinophil migration in vitro by 2,6-disubstituted pyridine analogs U-75,302 and U-75,485Prostaglandins42,211-224(1991)
Silbaugh, S.A., Stengel, P.W., Cockerham, S.L., et al.Pulmonary actions of LY255283, a leukotriene B4 receptor antagonistEur. J. Pharmacol.223,57-64(1992)
Yokomizo, T., Kato, K., Hagiya, H., et al.Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2J. Biol. Chem.276(15),12454-12459(2001)
