Fiboflapon
Cat. No.：YN321042
| 产品名称: | Fiboflapon |
| CAS No.: | 936350-00-4 |
| Chemical Name: | 3-[(1,1-dimethylethyl)thio]-1-[[4-(6-ethoxy-3-pyridinyl)phenyl]methyl]-α,α-dimethyl-5-[(5-methyl-2-pyridinyl)methoxy]-1H-indole-2-propanoic acid |
| Synonyms: | GSK2190915; AM-803 |
| 分子量: | 637.83 |
| 分子式: | C₃₈H₄₃N₃O₄S |
| SMILES: | CC(C(O)=O)(C)CC1=C(SC(C)(C)C)C2=CC(OCC3=CC=C(C)C=N3)=CC=C2N1CC4=CC=C(C5=CN=C(OCC)C=C5)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fiboflapon (GSK2190915; AM-803) 是一种口服有效的 5-脂氧合酶激活蛋白 (FLAP) 抑制剂，结合 FLAP 的效价为 2.9 nM，在人血中抑制LTB4的IC50为 76 nM。 |
| IC50和靶点: | [{name:"LTB4:76 nM (IC50)"}] |
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| Solvent & Solubility: |
Lorrain, D.S., Bain, G., Correa, L.D., et al.Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammationEur. J. Pharmacol.640(1-3),211-218(2010)
