Zafirlukast
Cat. No.：YN321146
| 产品名称: | Zafirlukast |
| CAS No.: | 107753-78-6 |
| Chemical Name: | [3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-1H-indol-5-yl]-carbamic acid, cyclopentyl ester |
| Synonyms: | 扎鲁司特; ICI 204219 |
| 分子量: | 575.68 |
| 分子式: | C₃₁H₃₃N₃O₆S |
| SMILES: | O=C(OC1CCCC1)NC2=CC3=C(N(C)C=C3CC4=CC=C(C(NS(=O)(C5=CC=CC=C5C)=O)=O)C=C4OC)C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Zafirlukast 是一种有效的具有口服活性的白三烯 D4(LTD4) 受体拮抗剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Chen, H., Yang, H., Wang, Z., et al.Discovery of 3-substituted 1H-indole-2-carboxylic acid derivatives as a novel class of CysLT1 selective antagonistsACS Med. Chem. Lett.7(3),335-339(2016)
Liu, Y.-C., Khawaja, A.M., and Rogers, D.F.Effects of the cysteinyl leukotriene receptor antagonists pranlukast and zafirlukast on tracheal mucus secretion in ovalbumin-sensitized guinea-pigs in vitroBr. J. Pharmacol.124(3),563-571(1998)
Cabré, F., Carabaza, A., García, A.M., et al.Pharmacological profile of MEN91507, a new CysLT1 receptor antagonistEur. J. Pharmacol.451(3),317-326(2002)
